Bone, kidney & bladder
Antidiuretic hormone analogue
Desmopressin
Also known as: DDAVP, Noctiva
Best time
Bedtime
- 21:00–23:00
For night-time urination and bed-wetting, taken at bedtime to reduce urine made overnight.
Strong evidence
Consistent clinical trials or official prescribing guidance support this timing.
Why this time works
Normally, antidiuretic hormone rises at night to concentrate urine. When this rhythm is weak, too much urine is produced overnight. A bedtime dose replaces the missing night-time signal.
Body rhythm involved
Antidiuretic hormone (vasopressin) normally rises during sleep.