Stomach & gut
H2 receptor antagonist
Famotidine
Also known as: Pepcid
Best time
Bedtime
- 21:00–23:00
Bedtime dosing targets night-time acid, which peaks in the late evening.
Strong evidence
Consistent clinical trials or official prescribing guidance support this timing.
Why this time works
Basal acid secretion follows a circadian rhythm, rising in the late evening and peaking around 22:00–02:00. A bedtime H2 blocker suppresses this nocturnal acid, aiding ulcer healing and night-time reflux.
Body rhythm involved
Gastric acid secretion peaks around 22:00–02:00.