Pain & inflammation
Non-steroidal anti-inflammatory
Naproxen & other NSAIDs
Also known as: Aleve, ibuprofen, indomethacin
Best time
Depends on the condition
- 11:00–13:00· Osteoarthritis: before afternoon pain peak
- 19:00–21:00· Rheumatoid arthritis: evening for morning stiffness
Time the dose ahead of when your pain is worst: midday for osteoarthritis, evening for rheumatoid arthritis.
Moderate evidence
Supported by studies and drug pharmacology, but guidance varies between sources.
Why this time works
Osteoarthritis pain tends to build during the day with use, peaking late afternoon or evening. Rheumatoid arthritis pain and stiffness are worst in the morning. Dosing a few hours before each condition's peak gives better relief, and evening NSAIDs may cause fewer stomach side effects for some.
Body rhythm involved
OA pain rises with daytime use; RA inflammation peaks in the early morning.