Cancer therapy
Platinum chemotherapy
Oxaliplatin (chronomodulated)
Also known as: Eloxatin
Best time
Daytime infusion, peak ~16:00
- 10:00–22:00· Infusion, peak delivery ~16:00
Chronomodulated schedules deliver oxaliplatin during the day with a 16:00 peak.
Emerging evidence
Promising early or observational research — not yet standard practice everywhere.
Why this time works
Animal and human studies found oxaliplatin best tolerated in the afternoon. Combined with overnight 5-FU in the 'chronoFLO' regimen for colorectal cancer, it reduced toxicity in early trials.
Body rhythm involved
Detoxifying glutathione levels and cell cycles vary across the day.