Heart & blood pressure
Calcium channel blocker
Amlodipine
Also known as: Norvasc
Best time
Any time — keep it consistent
Very long-acting. Large trials found morning vs. evening blood-pressure dosing makes little difference to outcomes.
Mixed evidence
Studies disagree. Taking it at the same time every day matters more than the hour.
Why this time works
Amlodipine's 30–50 hour half-life keeps levels steady across 24 hours. Earlier studies suggested bedtime dosing of blood-pressure medicines reduced heart events, but the large UK TIME trial (2022, ~21,000 people) found no difference between morning and evening dosing.
Body rhythm involved
Blood pressure dips at night and surges in the early morning.