Heart & blood pressure
ACE inhibitor
Ramipril
Also known as: Altace, Tritace
Best time
Any time — consistency first
Bedtime dosing can lower night-time blood pressure more, but outcome trials disagree.
Mixed evidence
Studies disagree. Taking it at the same time every day matters more than the hour.
Why this time works
Some ACE inhibitors lower night-time blood pressure more when taken at bedtime, which may help 'non-dippers' whose pressure stays high overnight. However, the TIME trial showed no difference in heart attacks or strokes by dosing time. Your clinician may pick evening dosing based on 24-hour monitoring.
Body rhythm involved
The renin–angiotensin system is most active in the early morning.