Cholesterol
Statin · short half-life
Pravastatin
Also known as: Pravachol
Best time
Bedtime
- 20:00–23:00
A short-acting statin usually taken at bedtime to match night-time cholesterol production.
Moderate evidence
Supported by studies and drug pharmacology, but guidance varies between sources.
Why this time works
With a half-life of about 1–3 hours, pravastatin works best when taken shortly before the overnight surge in cholesterol synthesis. Some studies show modest extra benefit from evening dosing.
Body rhythm involved
Hepatic cholesterol synthesis peaks overnight.