Brain, mood & sleep
SSRI antidepressant
Fluoxetine
Also known as: Prozac
Best time
Morning
- 07:00–10:00
Usually taken in the morning because it can be activating and disturb sleep.
Moderate evidence
Supported by studies and drug pharmacology, but guidance varies between sources.
Why this time works
Fluoxetine can cause restlessness or insomnia in some people. Morning dosing keeps any stimulating effect in the daytime. Because its half-life is very long, the hour has little effect on blood levels.
Body rhythm involved
Sleep–wake rhythm; serotonin signalling helps regulate the body clock.