Brain, mood & sleep
NaSSA antidepressant
Mirtazapine
Also known as: Remeron
Best time
Bedtime
- 21:00–23:00
Strongly sedating, so it is taken at bedtime — often helping sleep in depression.
Strong evidence
Consistent clinical trials or official prescribing guidance support this timing.
Why this time works
Mirtazapine blocks histamine H1 receptors, causing drowsiness. Bedtime dosing turns this side effect into a benefit for people with poor sleep and reduces daytime grogginess.
Body rhythm involved
Aligns sedation with the night-time sleep window.